3/30/2010 PERMALINK
Mutation in the APC gene that causes the colon polyps that lead to cancer corrected by simple new technique. A team at the MD Anderson Cancer Center have found that a combination of Vitamin A acetate (RAc) and TRAIL, short for tumor necrosis factor-related apoptosis-inducing ligand, kills the precancerous polyps and inhibits tumor growth in mice that have deficiencies in a tumor-suppressor gene. That gene, adenomatous polyposis coli (APC) and its downstream signaling molecules, are mutated or deficient in 80 percent of all human colon cancers, said senior author Xiangwei Wu, Ph.D.